Expression of intramuscular extracellular matrix proteins in vastus lateralis muscle fibres between atrophic and non-atrophic COPD.

Background: Extracellular matrix (ECM) proteins are the major constituents of the muscle cell micro-environment, imparting instructive signalling, steering cell behaviour and controlling muscle regeneration. ECM remodelling is among the most affected signalling pathways in COPD and aged muscle. As a fraction of COPD patients present muscle atrophy, we questioned whether ECM composition would be altered in patients with peripheral muscle wasting (atrophic COPD) compared to those without muscle wasting (non-atrophic COPD). Methods: A set of ECM molecules with known impact on myogenesis were quantified in vastus lateralis muscle biopsies from 29 COPD patients (forced expiratory volume in 1 s 55±12% predicted) using ELISA and real-time PCR. COPD patients were grouped to atrophic or non-atrophic based on fat-free mass index (<17 or ≥17 kg·m-2). Results: Atrophic COPD patients presented a lower average vastus lateralis muscle fibre cross-sectional area (3872±258 µm2) compared to non-atrophic COPD (4509±198 µm2). Gene expression of ECM molecules was found significantly lower in atrophic COPD compared to non-atrophic COPD for collagen type I alpha 1 chain (COL1A1), fibronectin (FN1), tenascin C (TNC) and biglycan (BGN). In terms of protein levels, there were no significant differences between the two COPD cohorts for any of the ECM molecules tested. Conclusions: Although atrophic COPD presented decreased contractile muscle tissue, the differences in ECM mRNA expression between atrophic and non-atrophic COPD were not translated at the protein level, potentially indicating an accumulation of long-lived ECM proteins and dysregulated proteostasis, as is typically observed during deconditioning and ageing.

Lean Body Mass, Muscle Architecture and Powerlifting Performance during Preseason and in Competition.

Lean body mass (LBM) is correlated with powerlifting performance in athletes competing in different bodyweight classes. However, it remains unknown whether changes in LBM are correlated with performance changes in powerlifters preparing for a competition. The aim of this study was to investigate the changes in LBM and performance in powerlifters preparing for a competition. Eight male powerlifters (age 31.7 ± 9.8 years, height 1.77 ± 0.06 m, weight 99.2 ± 14.6 kg) and three female powerlifters (age 32.7 ± 16.3 years, height 1.54 ± 0.06 m, weight 66.6 ± 20.9 kg) participated in the study. The athletes followed individualized periodized training programs for 12 weeks, aiming to maximize their performance for the national championship. The maximum strength (1-RM) in the squat, bench press, and deadlift, body composition, handgrip strength, anaerobic power, quadriceps' cross-sectional area and vastus lateralis muscle architecture were measured before and after the training period. Significant increases were found after the training period in the squat (5.8 ± 7.0%, p < 0.05), bench press (4.9 ± 9.8%, p = 0.05) and deadlift (8.3 ± 16.7%, p < 0.05). Significant correlations were found between the 1-RM and LBM before and after the training period (r > 0.75, p < 0.05). The changes in the 1-RM after the training intervention correlated with the changes in the total LBM (p < 0.05). These results suggest that individual changes in LBM due to systematic resistance training for a competition may dictate increases in the 1-RM strength in powerlifters.

Fatigue and Metabolic Responses during Repeated Sets of Bench Press Exercise to Exhaustion at Different Ranges of Motion.

This study compared the acute effects of different ranges of motion (ROM) on fatigue and metabolic responses during repeated sets of bench press exercise. Ten resistance trained men performed three sets to momentary failure with two-min rest intervals at three different ROM: full ROM (FULL), and partial ROM in which the barbell was moved either at the bottom half (BOTTOM) or the top half (TOP) of the full barbell vertical displacement. In TOP, a higher load was lifted, and a higher total number of repetitions was performed compared to FULL and BOTTOM (130 ± 17.6 vs. 102.5 ± 15.9 vs. 98.8 ± 17.5 kg; 55.2 ± 9.8, 32.2 ± 6.5 vs. 49.1 ± 16.5 kg, respectively p < 0.01). Work per repetition was higher in FULL than TOP and BOTTOM (283 ± 43 vs. 205 ± 32 vs. 164 ± 31 J/repetition, p < 0.01). Mean barbell velocity at the start of set 1 was 21.7% and 12.8% higher in FULL compared to TOP and BOTTOM, respectively. The rate of decline in mean barbell velocity was doubled from set 1 to set 3 (p < 0.01) and was higher in FULL than both TOP and BOTTOM (p < 0.001). Also, the rate of mean barbell velocity decline was higher in BOTTOM compared to TOP (p = 0.045). Blood lactate concentration was similarly increased in all ROM (p < 0.001). Training at TOP ROM allowed not only to lift a higher load, but also to perform more repetitions with a lower rate of decline in mean barbell velocity. Despite the lower absolute load and work per repetition, fatigue was higher in BOTTOM than TOP and this may be attributed to differences in muscle length.

The Effect of Chronic Dietary Protein Manipulation on Amino Acids' Profile and Position Sense in the Elderly Suffering from Type 2 Diabetes Mellitus.

Dietary protein with adequate essential amino acids effectively stimulates protein synthesis and improves muscle mass. Musculoskeletal disorders in lower or upper limbs are not uncommon among patients with type II diabetes mellitus (T2DM). Therefore, this study primarily examines the effects of chronic dietary protein manipulation on amino acids' profile and position sense in the elderly suffering from T2DM. A total of 26 individuals suffering from non-insulin-dependent T2DM (age > 55 years old) participated in a 12 week nutritional intervention. The subjects were randomly assigned and the control group received 0.8-1.0 g protein/kg/day, while the intervention group received 1.2-1.5 g protein/kg/day. Lean body mass, muscle strength, and position sense were assessed at baseline, as well as at the 6th and 12th week of the intervention. Only in the intervention group, the essential amino acids intake met the current nutritional recommendations (p < 0.05), while, by the 12th week, only the intervention group showed significant improvement in the muscle strength of knee (p < 0.05) and shoulder (p < 0.05) extension. On the contrary, in the control group, a significant decline in appendicular lean mass (p < 0.05) was observed by the 12th week. Position sense at the knee joint revealed a tendency for improvement in the intervention group by the 12th week (main effect of time p = 0.072). In the present investigation, it was revealed that the higher protein intake in the intervention group seemed to have positive effects on muscle strength and nearly positive effects on position sense.

Muscle Ultrasound Echo Intensity and Fiber Type Composition in Young Females.

Ultrasonography has been extensively used to evaluate skeletal muscle morphology. The echo intensity, i.e., the mean pixel intensity of a specific region of interest in an ultrasound image, may vary among muscles and individuals with several intramuscular parameters presumed to influence it. The purpose of this study was to investigate the correlation between muscle echo intensity and muscle fiber type composition in humans. Thirteen female physical education students (age: 22.3 ± 5.4 years, height: 1.63 ± 0.06 m, body mass: 59.9 ± 7.4 kg) with no history of systematic athletic training participated in the study. Body composition with dual X-ray absorptiometry, leg-press maximum strength (1-RM), echo intensity, and the cross-sectional area (CSA) of the vastus lateralis (VL) muscle according to ultrasonography were measured. Muscle biopsies were harvested from the VL site where the echo intensity was measured. VL echo intensity was not significantly correlated with the percentage of type I muscle fibers or with the percentage area of type I muscle fibers. However, when VL echo intensity was corrected for the subcutaneous fat thickness at the site of the measurement, it was significantly correlated with the percentage of type I muscle fibers (r = 0.801, p < 0.01) and the percentage area of type I muscle fibers (r = 0.852, p < 0.01). These results suggest that the echo intensity of the vastus lateralis muscle corrected for the subcutaneous fat thickness at the measurement site may provide an estimate of the muscle fiber type composition, at least in young moderately trained females.

The Effects of Heavy Resisted Sled Pulling on Sprint Mechanics and Spatiotemporal Parameters.

ABSTRACT: Stavridis, I, Ekizos, A, Zisi, M, Agilara, G-O, Tsolakis, C, Terzis, G, and Paradisis, G. The effects of heavy resisted sled pulling on sprint mechanics and spatiotemporal parameters. J Strength Cond Res 37(12): 2346-2353, 2023-This study examines the effects of 2 resisted sled sprinting (RSS) training programs: with a load corresponding to the running velocity associated with the apex of the individual velocity-power relationship (50%vdec), with a load equal to 10% of body mass (10% BM), and of an unresisted sprint training (URS). We measured the 30-m sprint performance in intervals of 5 m examining sprint acceleration, mechanical properties (theoretical maximal horizontal power [Pmax], force [F0], velocity [v0], slope of the force-velocity relationship [SFv], maximal ratio of horizontal-to-resultant force [RFmax], rate of decrease in RF [Drf]), and spatiotemporal parameters (step frequency [SF], step length [SL], flight time [FT], and contact time [CT]). Twenty-seven sprinters were randomly assigned into the 50%vdec, 10% BM, and URS groups, performing 12 sessions over 6 consecutive weeks (2 sets of 5 sprints per session). The 50%vdec group significantly improved (p < 0.05) their performance in all 30-m intervals. Posttraining, the 50%vdec group showed significantly increased Pmax, F0, and RFmax (mean differences: 1.46 ± 1.70 W·kg-1, 0.51 ± 0.68 N·kg-1, and 0.17 ± 0.18%, respectively), compared with pretraining. The 50%vdec group achieved higher SF, whereas FT decreased postintervention. No significant changes (p > 0.05) were found in the performance and mechanical and spatiotemporal variables in the other groups. In conclusion, RSS training with a load of 50%vdec provides an effective loading stimulus to induce adaptations that improve sprint acceleration performance. The improvements are explained by greater amounts of force and power, efficient force application, and higher step frequencies.

Reactive Strength Index, Rate of Torque Development, and Performance in Well-Trained Weightlifters: A Pilot Study.

The purpose of this study was to investigate the correlation between the reactive strength index (RSI) using the drop jump (DJ) and the isometric rate of torque development (RTD) with weightlifting performance in national-level weightlifters. Seven male weightlifters (age: 28.3 ± 5.7 years, body mass: 80.5 ± 6.7 kg, body height: 1.73 ± 0.07 m) participated in this study. Measurements were performed 2 weeks prior to the national championship and included the countermovement jump (CMJ), the squat jump (SJ), the DJ from three different drop heights (20, 30, and 40 cm), and the isometric peak torque (IPT) and RTD. Performance in CMJ and SJ was significantly correlated with weightlifting performance (r ranging from 0.756 to 0.892). Significant correlations were found between weightlifting performance with DJ contact time (r ranging from -0.759 to -0.899) and RSI (r ranging from 0.790 to 0.922). Moreover, the best RSI was significantly correlated with the snatch (r = 0.921, p = 0.003) and total performance (r = 0.832, p = 0.020). Small to very large correlations were found between IPT and RTD with weightlifting performance (r ranging from 0.254 to 0.796). These results suggest that RSI and contact time variables from DJ may predict weightlifting performance in well-trained weightlifters. Additionally, IPT and RTD may provide useful insights into the neuromuscular fitness condition of the weightlifter.

Muscle Architecture Adaptations to Static Stretching Training: A Systematic Review with Meta-Analysis.

BACKGROUND: Long-term stretching of human skeletal muscles increases joint range of motion through altered stretch perception and decreased resistance to stretch. There is also some evidence that stretching induces changes in muscle morphology. However, research is limited and inconclusive. OBJECTIVE: To examine the effect of static stretching training on muscle architecture (i.e., fascicle length and fascicle angle, muscle thickness and cross-sectional area) in healthy participants. DESIGN: Systematic review and meta-analysis. METHODS: PubMed Central, Web of Science, Scopus, and SPORTDiscus were searched. Randomized controlled trials and controlled trials without randomization were included. No restrictions on language or date of publication were applied. Risk of bias was assessed using Cochrane RoB2 and ROBINS-I tools. Subgroup analyses and random-effects meta-regressions were also performed using total stretching volume and intensity as covariates. Quality of evidence was determined by GRADE analysis. RESULTS: From the 2946 records retrieved, 19 studies were included in the systematic review and meta-analysis (n = 467 participants). Risk of bias was low in 83.9% of all criteria. Confidence in cumulative evidence was high. Stretching training induces trivial increases in fascicle length at rest (SMD = 0.17; 95% CI 0.01-0.33; p = 0.042) and small increases in fascicle length during stretching (SMD = 0.39; 95% CI 0.05 to 0.74; p = 0.026). No increases were observed in fascicle angle or muscle thickness (p = 0.30 and p = 0.18, respectively). Subgroup analyses showed that fascicle length increased when high stretching volumes were used (p < 0.004), while no changes were found for low stretching volumes (p = 0.60; subgroup difference: p = 0.025). High stretching intensities induced fascicle length increases (p < 0.006), while low stretching intensities did not have an effect (p = 0.72; subgroup difference: p = 0.042). Also, high intensity stretching resulted in increased muscle thickness (p = 0.021). Meta-regression analyses showed that longitudinal fascicle growth was positively associated with stretching volume (p < 0.02) and intensity (p < 0.04). CONCLUSIONS: Static stretching training increases fascicle length at rest and during stretching in healthy participants. High, but not low, stretching volumes and intensities induce longitudinal fascicle growth, while high stretching intensities result in increased muscle thickness. REGISTRATION: PROSPERO, registration number: CRD42021289884.

Skeletal muscle fiber composition may modify the effect of nutrition on body composition in young females.

BACKGROUND AND AIM: The aim of this study was to investigate the hypothesis that healthy, normal-weight females with greater proportions and sizes of the oxidative muscle fibers would also be characterized by a healthier body composition compared with individuals with increased glycolytic fibers, even if both follow similar nutritional plans. METHODS AND RESULTS: Vastus lateralis muscle fiber-type composition, body composition through dual-energy X-ray absorptiometry, and dietary intakes through questionnaire were evaluated in twenty-two young, healthy, non-obese females (age: 21.3±1.8yrs, body mass: 67.5±6.2 kg, body height: 1.66±0.05m, body mass index (BMI): 24.2±2.6  kg m-2). The participants were allocated into two groups according to their type I muscle fibers percentage [high (HI) and low (LI)]. The participants of the LI group were characterized by significantly higher body mass, fat mass, BMI, and cross-sectional and percentage cross-sectional area (%CSA) of type IIx muscle fibers compared with participants of the HI group (p < 0.021). In contrast, the HI group was characterized by higher cross-sectional and %CSA of type I muscle fibers compared with the LI group (p < 0.038). Significant correlations were observed between body fat mass, lean body mass, total energy intake, fat energy intake, and %CSAs of type I and IIx muscle fibers (r: -0.505 to 0.685; p < 0.05). CONCLUSION: In conclusion, this study suggests that muscle fiber composition is an important factor that at least partly could explain the observed differential inter-individual responses of the body composition to nutrition in female individuals. Increased %CSAs of type I muscle fibers seem to act as a protective mechanism against obesity and favor a healthier body composition, neutralizing the negative effect of increased caloric fats intake on body composition, probably because of their greater oxidative metabolic properties and fat utilization capacities. In contrast, female individuals with low type I and high type IIx %CSAs of type I seem to be more metabolically inflexible and dietinduced obesity prone, even if they consume fewer total daily calories and fats.

Different eccentric-based power training volumes improve glycemic, lipidemic profile and body composition of females in a dose-dependent manner: Associations with muscle fibres composition adaptations.

The present study aimed to investigate the effect of different volumes of fast eccentric-based training on body composition and lipidemic-glycemic profiles in females, as well as to explore the relationship between the change in glycemic-lipidemic profiles and the change in muscle fibre composition. Twenty-nine young females were assigned into three groups and performed 10 weeks (2 training sessions per week) of either 3 (LV), 6 (MV) or 9 (HV) sets/session of four fast velocity eccentric-only half-squats against 70% of concentric 1RM, followed by 3 maximum countermovement jumps (CMJ) after each set. Body composition, vastus lateralis fibre-type composition, and resting blood lipidemic and glycemic indices were evaluated 1 week before and after the training intervention. Significant changes in body composition, fasting glucose, HOMA-IR and blood lipids were found after training with MV and HV (p < 0.05; η2: 0.135-0.390). Significant correlations were found between muscle fibres' percentage cross-sectional areas (%CSA) and resting glycemic-lipid values (r:-0.543to 0.730, p < 0.05). Training-induced changes of glycemic-lipid profiles were highly correlated to those of type IIa and IIx %CSAs (r: -0.895 to 0.898, p < 0.05). Partial Correlations revealed a significant impact of the imposed training volumes on these correlations. These results suggest that six but mostly nine sets per training session of the imposed training stimuli are needed for beneficial changes in resting glycemic-lipidemic profiles, changes which are related to the training-induced changes in muscle fibre composition. However, these relationships are dictated by the imposed training volumes.Highlights Power training induces beneficial changes in body composition, glycemic and lipidemic profiles.Greater training volumes are needed for the healthier changes in glycemic-lipidemic profiles.Higher Type I, IIA and lower IIX percentage cross-sectional areas are linked with healthier body composition and glycemic-lipidemic profiles.Individuals experiencing the greatest increase in Type IIa and decrease in Type IIX muscle fibres cross-sectional areas after power training are those with the greatest beneficial changes in body composition, glycemic and lipidemic profiles.

Effects of Dryland Training During the COVID-19 Lockdown Period on Swimming Performance.

PURPOSE: To examine the effect of dryland training during an 11-week lockdown period due to COVID-19 on swimming performance. METHODS: Twelve competitive swimmers performed 50- and 300-m maximum-effort tests in their preferred stroke and 200-, 400-, and four 50-m front crawl sprints (4 × 50 m) before and after the lockdown period. Critical speed as an index of aerobic endurance was calculated using (1) 50-, 300-, and (2) 200-, 400-m tests. Blood lactate concentration was measured after the 400- and 4 × 50-m tests. To evaluate strength-related abilities, the dryland tests included handgrip and shoulder isometric strength. Tethered swimming force was measured during a 10-second sprint. During the lockdown period, dryland training was applied, and the session rating of perceived exertion training (sRPE) load was recorded daily. RESULTS: sRPE training load during the lockdown was decreased by 78% (16%), and critical speed was reduced 4.7% to 4.9% compared to prelockdown period (P < .05). Performance time in 200, 300, and 400 m deteriorated 2.6% to 3.9% (P < .05), while it remained unaltered in 4 × 50- and 50-m tests (P > .05). Tethered force increased 9% (10%) (P < .01), but handgrip and shoulder isometric force remained unaltered (P > .05). Blood lactate concentration decreased 19% (21%) after the 400-m test and was unchanged following the 4 × 50-m tests (P > .05). CONCLUSIONS: Performance deterioration in the 200, 300, and 400 m indicates reduced aerobic fitness and impaired technical ability, while strength and repeated-sprint ability were maintained. When a long abstention from swimming training is forced, dryland training may facilitate preservation in short-distance but not middle-distance swimming performance.

Effects of Complex Vs. Compound Training on Competitive Throwing Performance.

ABSTRACT: Thomas, K, Spyridon, M, Nikolaos, Z, Angeliki-Nikolleta, S, Giorgos, K, Giorgos, G, and Gerasimos, T. Effects of complex vs. compound training on competitive throwing performance. J Strength Cond Res 36(7): 1866-1874, 2022-The purpose of this study was to investigate the effects of complex (CPX; strength and power exercises in pairs) vs. compound (CPD; strength and power exercises in different days) training on competitive track and field throwing performance. Ten well-trained throwers (7 male throwers and 3 female throwers) followed a 34-week periodized training program including 2 preparation periods. During the winter 4-week, precompetition phase, athletes were randomly assigned to CPX or CPD groups, while the opposite assignment was performed during the spring precompetition phase (counterbalanced design). Before and after each training period competitive track and field throwing performance, shot put throws, snatch, squat and bench press 1 repetition maximum (1RM), vertical jumps, rate of force development (RFD), and body composition were evaluated. Competitive track and field throwing performance increased significantly by 5.4 ± 2.9% and 1.9 ± 1.7%, after CPX and CPD, respectively, with a significant difference between groups (p < 0.001). Shot put throws and 1RM strength in bench press increased similarly after both programs (p < 0.05), but vertical jumps increased only after CPX training. CPX induced greater increases in 1RM strength in snatch and squat, RFD, and lean body mass compared with CPD (p < 0.005). The linear combination of training-induced changes in RFD 150ms, 1RM in squat, snatch, and total lean mass explained the 80% of the percentage increase in competitive track and field throwing performance (p = 0.007). These results suggest that 4 weeks of CPX training during the precompetition period induce greater increases in competitive track and field throwing performance, 1RM strength, power, and RFD compared with CPD training.

Acute and Long-Term Effects of Concurrent Resistance and Swimming Training on Swimming Performance.

Dry-land resistance exercise (RT) is routinely applied concurrent to swimming (SWIM) training sessions in a year-round training plan. To date, the impact of the acute effect of RT on SWIM or SWIM on RT performance and the long-term RT-SWIM or SWIM-RT training outcome has received limited attention. The existing studies indicate that acute RT or SWIM training may temporarily decrease subsequent muscle function. Concurrent application of RT-SWIM or SWIM-RT may induce similar physiological alterations. Such alterations are dependent on the recovery duration between sessions. Considering the long-term effects of RT-SWIM, the limited existing data present improvements in front crawl swimming performance, dry-land upper and lower body maximum strength, and peak power in swim turn. Accordingly, SWIM-RT training order induces swimming performance improvements in front crawl and increments in maximum dry-land upper and lower body strength. Concurrent application of RT-SWIM or SWIM-RT training applied within a training day leads in similar performance gains after six to twelve weeks of training. The current review suggests that recovery duration between RT and SWIM is a predisposing factor that may determine the training outcome. Competitive swimmers may benefit after concurrent application with both training order scenarios during a training cycle.

Effect of Inter-Repetition Rest Vs. Traditional Resistance Training on The Upper Body Strength Rate of Force Development and Triceps Brachii Muscle Architecture.

The purpose of the study was to examine the effect of seven-week inter-repetition rest vs. traditional resistance training on upper body maximum strength, the rate of force development and triceps brachii muscle architecture. Sixteen male participants were equally assigned into the inter-repetition rest and the traditional group. In both groups, training included the bench press exercise performed with 4 sets of 6 maximum repetitions, two training sessions per week. Twenty-second inter-repetition rest was employed for the inter-repetition rest group only. Measurements before and after the training period included maximum strength in the bench press, the isometric upper body rate of force development and peak force and triceps brachii muscle architecture. Maximum strength increased significantly in both groups (inter-repetition rest group: 21.5 ± 5.7% vs. traditional group: 13.5 ± 7.2%, p < 0.05), however, the maximum strength percentage increase was greater in the inter-repetition rest group compared to the traditional group (p = 0.027). Upper body isometric peak force increased only after inter-repetition rest training (10.7 ± 10.3%, p = 0.009). The rate of force development remained unchanged for both groups (p > 0.05), although percentage changes in time frames of 0-80 and 0-100 milliseconds were greater for the inter-repetition rest group compared to the traditional training group (p = 0.024 and p = 0.044, respectively). Triceps brachii thickness increased similarly for both groups (p < 0.05). These results suggest that inter-repetition rest may induce greater increases in maximum strength and the rate of force development compared to traditional training during the initial weeks of resistance training.

Evaluation of The Isometric and Dynamic Rates of Force Development in Multi-Joint Muscle Actions.

The rate of force development (RFD) in the isometric leg press (ILP), the countermovement jump (CMJ) and the squat jump (SJ) were examined in twenty-three (9 females) team sport athletes aged 21-24 years. Peak force (Fpeak), peak rate of force development (RFDpeak) and RFD at different time epochs (0-50, 50-100, 100-150, 150-200) were calculated from the force-time curve, as well as CMJ and SJ height and the center of mass displacement. RFDpeak, RFD at 0-50, 50-100 and 100-150 ms and Fpeak were similar between the CMJ and the SJ (p = 0.26 to 0.99). Furthermore, RFD0-50 ms was similar between the ILP, the CMJ, and the SJ (p = 0.99 to 0.57). Higher values were observed in the ILP compared with the CMJ and the SJ in RFD50-100 ms and RFD100-150 ms (p < 0.001) and these differences were maintained even when RFD was scaled to body mass. The higher RFD normalized to Fpeak was attained at the 50-100 ms time interval with no differences between the ILP, CMJ and SJ and between males and females. These results suggest that the ability to exert rapid force is similar between the CMJ and the SJ, irrespective of the type of muscle action. Furthermore, RFD normalized to Fpeak is a muscle-force independent index of explosive force production, facilitating comparisons between individuals with different levels of muscle strength. The similarities between the CMJ and the SJ in RFDpeak, Fpeak, and RFD at different time epochs may imply that these types of jumps could be used interchangeably to assess explosive lower limb performance.

Preconditioning Strategies Before Maximum Clean Performance in Female Weightlifters.

ABSTRACT: Kelekian, GK, Zaras, N, Stasinaki, AN, Spiliopoulou, P, Karampatsos, G, Bogdanis, G, and Terzis, G. Preconditioning strategies before maximum clean performance in female weightlifters. J Strength Cond Res 36(8): 2318-2321, 2022-The aim of the study was to examine the acute effect of performing clean pulls with either 85% or 120% one repetition maximum (1RM), on subsequent clean performance, in female Olympic weightlifters. Eight competitive female Olympic weightlifters (age, 22.9 ± 5.8 years; height, 1.67 ± 0.06 m; training experience, 6.1 ± 3.9 years; clean performance, 66.3 ± 3.9 kg), performed clean pulls either with 85% or with 120% 1RM, 3 minutes before their maximum effort in clean, in 2 different days, in a counterbalanced order. The rate of perceived exertion (RPE) was provided after each intervention. Body composition (dual x-ray absorptiometry), countermovement jumping (CMJ) performance, leg press isometric rate of force development (RFD), and peak force (PF) were also evaluated on different days. Clean performance was increased by 6.1 ± 3.6% ( p = 0.002) after preconditioning with 85% 1RM and 4.7 ± 3.1% ( p = 0.004) after 120% 1RM. Rate of perceived exertion was lower after preconditioning with 85% 1RM, compared with 120% 1RM ( p = 0.015). No significant correlation was found between the changes in clean performance after 85% or 120% 1RM, with lean body mass, CMJ performance, and isometric leg press RFD, and leg press PF. These data suggest that lifting either 85% or 120% 1RM in clean pulls is an effective strategy for acute increase of clean performance in female Olympic weightlifters, whereas the use of 85% 1RM load may be performed with less exertion.

Effectiveness of either short-duration ischemic pre-conditioning, single-set high-resistance exercise, or their combination in potentiating bench press exercise performance.

This study compared the effects of short-duration ischemic preconditioning, a single-set high-resistance exercise and their combination on subsequent bench press performance. Twelve men (age: 25.8 ± 6.0 years, bench press 1-RM: 1.21 ± 0.17 kg kg-1 body mass) performed four 12 s sets as fast as possible, with 2 min of recovery between sets, against 60% 1-RM, after: a) 5 min ischemic preconditioning (IPC; at 100% of full arterial occlusion pressure), b) one set of three bench press repetitions at 90% 1-RM (PAPE), c) their combination (PAPE + IPC) or d) control (CTRL). Mean barbell velocity in ischemic preconditioning was higher than CTRL (by 6.6-9.0%, p < 0.05) from set 1 to set 3, and higher than PAPE in set 1 (by 4.4%, p < 0.05). Mean barbell velocity in PAPE was higher than CTRL from set 2 to set 4 (by 6.7-8.9%, p < 0.05), while mean barbell velocity in PAPE + IPC was higher than CTRL only in set 1 (+5.8 ± 10.0%). Peak barbell velocity in ischemic preconditioning and PAPE was higher than CTRL (by 7.8% and 8.5%, respectively; p < 0.05). Total number of repetitions was similarly increased in all experimental conditions compared with CTRL (by 7.0-7.9%, p < 0.05). Rating of perceived exertion was lower in ischemic preconditioning compared with CTRL (p < 0.001) and PAPE (p = 0.045), respectively. These results highlight the effectiveness of short-duration ischemic preconditioning in increasing bench press performance, and suggest that it may be readily used by strength and conditioning coaches during resistance training due to its brevity and lower perceived exertion.

Body composition and 6 minute walking ability in late-onset pompe disease patients after 9 years of enzyme replacement therapy.

OBJECTIVE: Pompe disease is a rare autosomal recessive disorder caused by the deficiency of acid α-glycosidase resulting in accumulation of glycogen in the lysosomes. The late-onset form of the disease (LOPD) causes primarily progressive muscle weakness and respiratory insufficiency. Enzyme replacement therapy (ERT) introduced in 2006, showed mild improvement or stabilization of the symptoms although long-term data are limited. Aim of the study was to describe the progression of body composition and walking ability in LOPD patients receiving ERT consistently for 9 years. METHODS: Lean body mass, bone mineral density, body fat and 6 min walking distance were assessed in three male and three female LOPD patients (height 165.8 ± 11.2 cm, age 42.3 ± 11.8yrs, body mass 71.1 ± 20.8 kg, at study entry), every three years, for 9 years since ERT initiation (T0, T3, T6, T9). RESULTS: Total body and upper extremities' lean mass remained unchanged (p < 0.05), but it was decreased for the lower extremities (T3:13.06 ± 3.848 kg vs. T9:11.63 ± 3.49 kg, p < 0.05). Lean body mass was not significantly different after 9 years of ERT compared to before the ERT initiation (T0 to T9). Bone mineral density remained unchanged. Percent body fat increased (T0:39.1 ± 10.3%, vs. T9:43.1 ± 10.4%, p < 0.05). Six minute walking distance tended to increase after 3 years of ERT and decreased gradually thereafter, with no difference between T0-T9. Lean mass of the lower extremities adjusted for body weight was significantly correlated with 6 min walking distance (r = 0.712, p < 0.05). CONCLUSION: The current data show that enzyme replacement therapy may preserve lean body mass, bone mineral density and walking capacity in LOPD patients.

Seven months of aerobic intradialytic exercise training can prevent muscle loss in haemodialysis patients: an ultrasonography study.

PURPOSE: This study aimed to evaluate the effects of 7-month intradialytic exercise training (IDE) on vastus lateralis (VL) muscle architecture, functional capacity and quality of life in stable haemodialysis (HD) patients. METHODS: 44 HD patients were randomly assigned into an Exercise Group (EG = 21), which they received 7 months of IET, at 60% of pre-assessed maximum aerobic power, 3/week) or into a Control Group (CG = 23, no exercise). VL architecture was evaluated with ultrasonography, functional capacity was assessed using a series of functional tests (6 min walking test, 5 repetitions sit-to-stand, sit-to-stand 60 s, handgrip strength), and maximal aerobic power determined with a modified version of the Åstrand test. Quality of life and fatigue levels were evaluated using validated questionnaires. RESULTS: VL fascicle angle and length did not change significantly in both groups (P > 0.05). Muscle thickness decreased in CG (P = 0.02) while it was fully preserved in the EG. Functional capacity increased only in the EG (6 min walking test 15.79 ± 12.35%, P < 0.001; max aerobic power 26.36 ± 1.24%, P < 0.001; STS-60rep: 10.23 ± 1.60%, P < 0.000; hand grip strength: 5.14 ± 28.30%, P < 0.02). CONCLUSION: Intradialytic aerobic exercise training, improves functional capacity and prevents thigh muscle mass loss in HD patients. It is evident that muscle ultrasonography could play a pivotal role in assessing muscle quality changes in haemodialysis patients. A higher level of training intensity or combination with resistance exercises may be required to further improve anabolism and influence muscle architecture in this patient population. CLINICAL TRIAL REGISTRY NUMBER: NCT03905551.

Muscle Architectural and Functional Adaptations Following 12-Weeks of Stretching in Adolescent Female Athletes.

This study examined the effects of high-volume static stretching training on gastrocnemius muscle architecture, ankle angle and jump height in 21 female adolescent volleyball players. Static stretching of the plantar flexors of one leg (STR) was performed five times/week for 12 weeks, in addition to volleyball training, with the contra-lateral leg used as control (CON). Total duration of stretching per session increased from 540 s (week 1) to 900 s (week 12). At baseline, week 12 and after 3 weeks of detraining, muscle architecture at the middle and the distal part of both gastrocnemius heads (medialis and lateralis) and ankle angle were examined at rest and at maximum dorsiflexion. At the same time-points gastrocnemius cross-sectional area (CSA) was also assessed, while jumping height was measured at baseline and week 12. Following intervention, ankle dorsiflexion increased in both legs with a greater increase in STR than CON (22 ± 20% vs. 8 ± 17%, p < 0.001). Fascicle length at the middle part of gastrocnemius medialis increased only in the STR, at rest (6 ± 7%, p = 0.006) and at maximum dorsiflexion (11 ± 7%, p < 0.001). Fascicle length at maximum dorsiflexion also increased at the distal part of gastrocnemius lateralis of STR (15 ± 13%, p < 0.001). A greater increase in CSA (23 ± 14% vs. 13 ± 14%, p < 0.001) and in one-leg jumping height (27 ± 30% vs. 17 ± 23%, p < 0.001) was found in STR than CON. Changes in ankle angle, fascicle length and CSA were maintained following detraining. High-volume stretching training for 12 weeks results in ankle dorsiflexion, fascicle length and muscle cross sectional area increases in adolescent female volleyball players. These adaptations may partly explain improvements in jump performance.